Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ MMP-2 Substrate, Fluorogenic
A quenched fluorescence substrate for MMP-2 (gelatinase A; kcat/Km = 3.97 x 105 M-1s-1).
MilliporeSigma™ Calbiochem™ Aromatase Inhibitor I
The Aromatase Inhibitor I, also referenced under CAS 331684-05-0, controls the biological activity of Aromatase.
MilliporeSigma™ Calbiochem™ InSolution™ SU6656
A potent inhibitor of Src-family protein tyrosine kinases
MilliporeSigma™ Calbiochem™ AG 490
A cell-permeable, reversible, substrate competitive, and potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50 = 100 nM).
MilliporeSigma™ Calbiochem™ Gö 6976
Gö 6976, CAS 136194-77-9, is a cell-permeable, reversible, and ATP-competitive inhibitor of PKC (IC50 = 7.9 nM for rat brain). Exhibits selectively for PKCα (IC50 = 2.3 nM) and βI (IC50 = 6.2 nM).
MilliporeSigma™ Calbiochem™ IL-2Rα Antagonist
The IL-2Rα Antagonist, also referenced under CAS 1217448-66-2, controls the biological activity of IL-2Rα.
MilliporeSigma™ Calbiochem™ Cathepsin B Inhibitor II
The Cathepsin B Inhibitor II controls the biological activity of Cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ Ilimaquinone
A cell-permeable marine sponge metabolite with anti-microbial, anti-HIV, anti-inflammatory, and anti-mitotic properties.
MilliporeSigma™ Calbiochem™ Bcl-2 Inhibitor II, YC137
The Bcl-2 Inhibitor II, YC137, also referenced under CAS 810659-53-1, controls the biological activity of Bcl-2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
MilliporeSigma™ Calbiochem™ Bisindolylmaleimide I, Hydrochloride
An enhanced water-soluble form of Bisindolylmaleimide I.
MilliporeSigma™ Calbiochem™ JAK Inhibitor I
JAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC50 = 15 nM), JAK2 (IC50 = 1 nM), JAK3 (Ki = 5 nM) and Tyk2 (IC50 = 1 nM).
MilliporeSigma™ Calbiochem™ IκB Kinase Inactive Control Peptide, Cell-Permeable
An inactive control for IκB Kinase Inhibitor Peptide.
MilliporeSigma™ Calbiochem™ Telomerase Inhibitor X, BIBR1532
A cell-permeable, selective, highly potent, non-nucleotide competitive inhibitor of telomerase activity (IC50 = 93 nM in HeLa cells nuclear extracts).
MilliporeSigma™ Calbiochem™ Calpastatin Peptide
A 27-amino acid, cell-permeable peptide encoded by exon 1B of human calpastatin that acts as a potent inhibitor of calpain I and calpain II (IC50 = 20 nM for purified rabbit calpain II).
MilliporeSigma™ Calbiochem™ InSolution™ 5-Aza-2'-Deoxycytidine
A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines.