Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ AGE Inhibitor, LR-90
A cell-permeable blocker of advanced glycation end product formation.
MilliporeSigma™ Calbiochem™ TrkB Agonist, 7,8-Dihydroxyflavone
A cell permeable flavone based compound with neurotrophic and neuroprotective properties
MilliporeSigma™ Calbiochem™ InSolution™ IKK Inhibitor VII
A cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40, 70, and 200nM for IKK-2, IKK complex, and IKK-1, respective
MilliporeSigma™ Calbiochem™ Late Endosome Trafficking Inhibitor, EGA
A cell-permeable compound that prevents various bacterial toxins from exerting their cytotoxic activity by blocking endosomal trafficking/maturation into acidified late endosomes.
MilliporeSigma™ Calbiochem™ CD45 Inhibitor VI
A cell-permeable, potent, irreversible, non-substrate competitive inhibitor of CD45/PTPRC tyrosine phosphatase activity (IC50 = 290 nM).
MilliporeSigma™ Calbiochem™ SKP2 E3 Ligase Inhibitor IV
A cell-permeable inhibitor of SKP2-dependent p27Kip1 ubiquitination. Selectively induces the accumulation SCFSKP2 substrates in multiple myeloma RPMI 8226 cells.
Novus Biologicals™ Celastrol, IL-17A (IL-17A Inhibitor)
Used in assays to inhibit IL-17A induction
MilliporeSigma™ Calbiochem™ IRAP Inhibitor, HFI-419
A substrate competitive inhibitor of insulin-regulated aminopeptidase (IRAP) activity (Ki = 0.48 μM against 25 μM Leu-AMC).
MilliporeSigma™ Calbiochem™ NS309
A potent activator of Ca2+ -activated K+ channels of SK and IK types, but not BK type channels. It is at least 1000 times more potent than 1-EBIO.
MilliporeSigma™ Calbiochem™ (+/-)-Clopidogrel Hydrogensulfate
A thienopyridine compound that acts as a specific irreversible inhibitor of purinergic P2Y12 recept
MilliporeSigma™ Calbiochem™ BMI-1 Expression Inhibitor, PTC-209
A cell-permeable compound that downregulates cellular BMI-1 levels by inhibiting BMI-1 transcription.
MilliporeSigma™ Calbiochem™ GPR40 Agonist III
A cell-permeable, highly potent, and selective agonist of free fatty acid receptor 1 (FFA1; GPR40; EC50 = 20 nM in FFA1-transfected HEK-293 cells).
MilliporeSigma™ Calbiochem™ gp130 Inhibitor, SC144
Cell-permeable inhibitor of gp130. Binds to gp130 and induces its phosphorylation at Ser782 in ovarian cancer cells. Suppresses constitutive phosphorylation of and nuclear translocation of Stat3.
MilliporeSigma™ Calbiochem™ DUB Inhibitor XI
A cell-permeable compound that acts as a dual inhibitor of USP7 (IC50 = 0.42 μM) and USP47 (IC50 = 1.0 μM).